SnapShot: B7/CD28 Costimulation
نویسندگان
چکیده
B7-1 (CD80) Inducible: APCs (slower kinetics than B7-2), T cells CD28 Constitutive: mouse (all T cells), human (95% of CD4+, 50% of CD8+ T cells), plasma cells, NK cells Stimulation of naive and previously activated T cells upon TCR ligation: ↑ proliferation (↓ p27Kip1, ↑ G1/S); ↑ cytokine production (↑ NFκB, ↑ IL2); ↑ survival (↑ Bcl-xL, ↑ survival of Tregs); ↑ glucose metabolism; provides T cell-dependent B cell help for class switching. Blockade of pathway to treat autoimmune infl ammatory diseases and for transplantation; active engagement to expand anti-tumor T cells and Tregs B7-2 (CD86) Constitutive at low levels; inducible: APCs, T cells
منابع مشابه
The capacity of the natural ligands for CD28 to drive IL-4 expression in naïve and antigen-primed CD4+ and CD8+ T cells.
The B7/CD28 costimulatory pathway plays a critical role in T cell activation including Th1/Th2 differentiation. However, little is known about whether CD28 costimulation favors polarization of either Th1 and Th2 or both. Here, we show a critical role of the natural ligands for CD28 molecules (B7.2-Ig or B7.1-Ig fusion proteins), particularly in the induction of type 2 T cell polarization. Upon ...
متن کاملThe capacity of the natural ligands for CD28 to drive IL-4 expression in naı̈ve and antigen-primed CD4 and CD8 T cells
The B7/CD28 costimulatory pathway plays a critical role in T cell activation including Th1/Th2 differentiation. However, little is known about whether CD28 costimulation favors polarization of either Th1 and Th2 or both. Here, we show a critical role of the natural ligands for CD28 molecules (B7.2–Ig or B7.1–Ig fusion proteins), particularly in the induction of type 2 T cell polarization. Upon ...
متن کاملThe role of B7 costimulation in CD4/CD8 T cell homeostasis.
The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice resulted in marked polyclonal peripheral T cell hyperplasia accompanied by skewing toward an increased proportion of CD8 single-positive cells and a decreased proportion of CD4 single-positive cells in ...
متن کاملCritical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.
CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in the absence of CD28 costimulation, cells are not primed to produce Th2 cytokin...
متن کاملExpression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection.
CD28 interactions promote T cell responses, and whether B7-1 or B7-2 is utilized may influence Th cell subset development. CD28 blockade by CTLA-4Ig treatment or by targeted gene disruption has yielded different conclusions regarding the role of CD28 in the development of Th1 and Th2 cells following Leishmania major infection. In this study, we demonstrate that B7-mediated costimulation is requ...
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عنوان ژورنال:
- Cell
دوره 137 شماره
صفحات -
تاریخ انتشار 2009